Metropolitan Atlanta Congenital Defects Program
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Race/Ethnicity
Total * Notes
White,
Non-Hispanic
Black,
Non-Hispanic
Hispanic,
Non-Hispanic
Asian or
Pacific Islander,
Non-Hispanic
American Indian
or Alaskan Native,
Non-Hispanic
Anencephaly 5 (1.2) 7 (1.0) <5 (†) <5 (†) 0 (0.0) 19 (1.1)
Anophthalmia / microphthalmia 5 (1.2) 16 (2.3) <5 (†) 0 (0.0) 0 (0.0) 24 (1.4)
Anotia / microtia 8 (1.8) 11 (1.6) 17 (5.2) <5 (†) 0 (0.0) 41 (2.5)
Aortic valve stenosis 9 (2.1) 13 (1.9) <5 (†) <5 (†) <5 (†) 29 (1.7)
Atrial septal defect 116 (26.8) 257 (36.7) 113 (34.6) 37 (23.9) 0 (0.0) 534 (31.9)
Atrioventricular septal defect (endocardial cushion defect) 18 (4.2) 59 (8.4) 20 (6.1) 5 (3.2) 0 (0.0) 106 (6.3)
Biliary atresia <5 (†) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 7 (0.4)
Bladder exstrophy <5 (†) 0 (0.0) 0 (0.0) <5 (†) 0 (0.0) <5 (†)
Choanal atresia <5 (†) <5 (†) <5 (†) <5 (†) 0 (0.0) 10 (0.6)
Cleft lip alone (without cleft palate) 16 (3.7) 11 (1.6) 7 (2.1) 8 (5.2) 0 (0.0) 42 (2.5)
Cleft lip with cleft palate 15 (3.5) 28 (4.0) 23 (7.0) 7 (4.5) <5 (†) 74 (4.4)
Cleft palate alone (without cleft lip) 25 (5.8) 32 (4.6) 18 (5.5) 17 (11.0) 0 (0.0) 92 (5.5)
Cloacal exstrophy 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) 0 (0.0) <5 (†)
Clubfoot 67 (15.5) 109 (15.5) 54 (16.5) 13 (8.4) 0 (0.0) 254 (15.2)
Coarctation of aorta 19 (4.4) 39 (5.6) 12 (3.7) 6 (3.9) 0 (0.0) 77 (4.6)
Common truncus (truncus arteriosus or TA) <5 (†) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 8 (0.5)
Congenital cataract 13 (3.0) 26 (3.7) 10 (3.1) <5 (†) 0 (0.0) 51 (3.0)
Congenital posterior urethral valves <5 (†) 19 (5.4) <5 (†) 5 (6.3) 0 (0.0) 31 (3.6) 1
Craniosynostosis 54 (12.5) 41 (5.8) 22 (6.7) 10 (6.5) 0 (0.0) 131 (7.8)
Deletion 22q11.2 6 (1.4) 20 (2.9) <5 (†) <5 (†) <5 (†) 35 (2.1)
Dextro-Transposition of great arteries (d-TGA) 8 (1.8) 24 (3.4) 7 (2.1) <5 (†) 0 (0.0) 42 (2.5)
Diaphragmatic hernia 7 (1.6) 13 (1.9) 12 (3.7) <5 (†) <5 (†) 36 (2.2)
Double outlet right ventricle (DORV) 6 (1.4) 21 (3.0) 11 (3.4) <5 (†) 0 (0.0) 41 (2.5)
Ebstein anomaly <5 (†) <5 (†) <5 (†) <5 (†) 0 (0.0) 9 (0.5)
Encephalocele <5 (†) 11 (1.6) <5 (†) <5 (†) 0 (0.0) 17 (1.0)
Esophageal atresia / tracheoesophageal fistula 14 (3.2) 20 (2.9) 9 (2.8) <5 (†) 0 (0.0) 47 (2.8)
Gastroschisis 6 (1.4) 14 (2.0) 13 (4.0) <5 (†) 0 (0.0) 36 (2.2)
Holoprosencephaly 0 (0.0) 17 (2.4) <5 (†) <5 (†) 0 (0.0) 24 (1.4)
Hypoplastic left heart syndrome 11 (2.5) 19 (2.7) <5 (†) <5 (†) 0 (0.0) 38 (2.3)
Hypospadias 239 (107.6) 339 (95.5) 71 (43.0) 54 (68.3) <5 (†) 729 (85.7) 1
Interrupted aortic arch (IAA) <5 (†) 9 (1.3) 0 (0.0) 0 (0.0) 0 (0.0) 11 (0.7)
Limb deficiencies (reduction defects) 20 (4.6) 44 (6.3) 13 (4.0) <5 (†) 0 (0.0) 84 (5.0)
Omphalocele 8 (1.8) 24 (3.4) <5 (†) <5 (†) 0 (0.0) 39 (2.3)
Pulmonary valve atresia 11 (2.5) 26 (3.7) 9 (2.8) <5 (†) 0 (0.0) 50 (3.0)
Pulmonary valve atresia and stenosis 41 (9.5) 95 (13.5) 31 (9.5) 8 (5.2) 0 (0.0) 178 (10.6)
Rectal and large intestinal atresia / stenosis 19 (4.4) 29 (4.1) 16 (4.9) 10 (6.5) 0 (0.0) 77 (4.6)
Renal agenesis / hypoplasia 37 (8.6) 37 (5.3) 13 (4.0) 10 (6.5) 0 (0.0) 102 (6.1)
Single ventricle <5 (†) 10 (1.4) 7 (2.1) 0 (0.0) 0 (0.0) 20 (1.2)
Small intestinal atresia / stenosis 10 (2.3) 28 (4.0) 13 (4.0) <5 (†) 0 (0.0) 54 (3.2)
Spina bifida without anencephaly 12 (2.8) 15 (2.1) 16 (4.9) 0 (0.0) 0 (0.0) 43 (2.6)
Tetralogy of Fallot (TOF) 34 (7.9) 59 (8.4) 20 (6.1) 12 (7.8) 0 (0.0) 129 (7.7)
Total anomalous pulmonary venous connection (TAPVC) <5 (†) 8 (1.1) 7 (2.1) 0 (0.0) 0 (0.0) 18 (1.1)
Transposition of the great arteries (TGA) 9 (2.1) 27 (3.9) 9 (2.8) <5 (†) 0 (0.0) 48 (2.9)
Tricuspid valve atresia <5 (†) 6 (0.9) <5 (†) 0 (0.0) 0 (0.0) 11 (0.7)
Tricuspid valve atresia and stenosis <5 (†) 16 (2.3) 5 (1.5) 0 (0.0) 0 (0.0) 25 (1.5)
Trisomy 13 5 (1.2) 17 (2.4) <5 (†) <5 (†) 0 (0.0) 29 (1.7)
Trisomy 18 <5 (†) 25 (3.6) 9 (2.8) <5 (†) 0 (0.0) 46 (2.8)
Trisomy 21 (Down syndrome) 49 (11.3) 93 (13.3) 68 (20.8) 5 (3.2) 0 (0.0) 222 (13.3)
Turner syndrome 7 (3.3) 8 (2.3) <5 (†) <5 (†) 0 (0.0) 21 (2.6) 2
Ventricular septal defect 370 (85.5) 380 (54.2) 321 (98.3) 101 (65.4) <5 (†) 1211 (72.4)
Total live births 43274 70122 32652 15449 111 167250 3
Male Live Births 22205 35493 16517 7905 51 85032
Female Live Births 21069 34628 16135 7544 60 82217
Notes
1- Data for this condition include male and unknown infant sex cases only. Prevalence is calculated per 10,000 male live births.
2- Data for this condition include female and unknown infant sex cases only. Prevalence is calculated per 10,000 female live births.
3- Data for total live births include unknown infant sex.

General comments
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other race
Metropolitan Atlanta Congenital Defects Program
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Age
Total *
Less than 35 years 35 of more years
Gastroschisis 34 (2.7) <5 (†) 36 (2.2)
Trisomy 13 16 (1.3) 9 (2.3) 29 (1.7)
Trisomy 18 15 (1.2) 27 (6.8) 46 (2.8)
Trisomy 21 (Down syndrome) 94 (7.4) 121 (30.3) 222 (13.3)
Total live births 127235 39995 167250
Notes
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other maternal age
Metropolitan Atlanta Congenital Defects Program
Notes on Specific Birth Defects
Defect Site Comment
Universal comment Live births include gestational ages greater than or equal to 20 weeks.
Universal comment Stillbirths include gestational ages greater than or equal to 20 weeks.
Universal comment Elective terminations include all gestational ages.
Universal comment Cases for which the date of delivery was unknown are included in the year of their last known prenatal test.