Colorado
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Race/Ethnicity
Total * Notes
White,
Non-Hispanic
Black,
Non-Hispanic
Hispanic,
Non-Hispanic
Asian or
Pacific Islander,
Non-Hispanic
American Indian
or Alaskan Native,
Non-Hispanic
Anencephaly 6 (0.3) <5 (†) 6 (0.7) <5 (†) 0 (0.0) 25 (0.8)
Anophthalmia / microphthalmia 21 (1.1) <5 (†) 12 (1.3) <5 (†) <5 (†) 39 (1.2)
Anotia / microtia 52 (2.8) <5 (†) 44 (4.8) 7 (5.3) 0 (0.0) 110 (3.5)
Aortic valve stenosis 51 (2.8) <5 (†) 21 (2.3) <5 (†) <5 (†) 82 (2.6)
Atrial septal defect 3176 (172.0) 284 (183.4) 1581 (172.9) 195 (146.9) 39 (217.4) 5470 (174.9)
Atrioventricular septal defect (endocardial cushion defect) 40 (2.2) 6 (3.9) 26 (2.8) <5 (†) 0 (0.0) 79 (2.5)
Biliary atresia 30 (1.6) 7 (4.5) 26 (2.8) <5 (†) 0 (0.0) 67 (2.1)
Bladder exstrophy <5 (†) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) <5 (†)
Choanal atresia 45 (2.4) <5 (†) 18 (2.0) <5 (†) <5 (†) 72 (2.3)
Cleft lip alone (without cleft palate) 50 (2.7) <5 (†) 21 (2.3) <5 (†) 0 (0.0) 77 (2.5)
Cleft lip with cleft palate 71 (3.8) <5 (†) 44 (4.8) <5 (†) 0 (0.0) 135 (4.3)
Cleft palate alone (without cleft lip) 103 (5.6) 9 (5.8) 47 (5.1) 14 (10.5) <5 (†) 184 (5.9)
Cloacal exstrophy <5 (†) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) <5 (†)
Clubfoot 402 (21.8) 28 (18.1) 173 (18.9) 30 (22.6) <5 (†) 658 (21.0)
Coarctation of aorta 94 (5.1) 9 (5.8) 45 (4.9) 6 (4.5) <5 (†) 158 (5.1)
Common truncus (truncus arteriosus or TA) 10 (0.5) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) 16 (0.5)
Congenital cataract 41 (2.2) <5 (†) 18 (2.0) <5 (†) 0 (0.0) 66 (2.1)
Congenital posterior urethral valves 18 (1.9) 6 (7.7) 9 (1.9) <5 (†) 0 (0.0) 36 (2.2) 1
Craniosynostosis 270 (14.6) 17 (11.0) 144 (15.7) 9 (6.8) <5 (†) 453 (14.5)
Deletion 22q11.2 22 (1.2) <5 (†) 16 (1.7) 0 (0.0) <5 (†) 44 (1.4)
Dextro-Transposition of great arteries (d-TGA) 24 (1.3) 0 (0.0) 9 (1.0) 0 (0.0) 0 (0.0) 44 (1.4)
Diaphragmatic hernia 46 (2.5) <5 (†) 22 (2.4) <5 (†) <5 (†) 79 (2.5)
Double outlet right ventricle (DORV) 16 (0.9) <5 (†) 13 (1.4) <5 (†) <5 (†) 38 (1.2)
Ebstein anomaly 8 (0.4) 0 (0.0) <5 (†) <5 (†) 0 (0.0) 13 (0.4)
Encephalocele 9 (0.5) <5 (†) 7 (0.8) <5 (†) 0 (0.0) 20 (0.6)
Esophageal atresia / tracheoesophageal fistula 80 (4.3) <5 (†) 21 (2.3) <5 (†) 0 (0.0) 110 (3.5)
Gastroschisis 27 (1.5) <5 (†) 24 (2.6) <5 (†) <5 (†) 60 (1.9)
Holoprosencephaly <5 (†) <5 (†) <5 (†) <5 (†) 0 (0.0) 11 (0.4)
Hypoplastic left heart syndrome 36 (1.9) <5 (†) 13 (1.4) <5 (†) <5 (†) 58 (1.9)
Hypospadias 1208 (127.7) 76 (97.8) 296 (63.3) 61 (89.5) <5 (†) 1699 (106.2) 1
Interrupted aortic arch (IAA) 16 (0.9) <5 (†) 15 (1.6) <5 (†) 0 (0.0) 41 (1.3)
Limb deficiencies (reduction defects) 41 (2.2) <5 (†) 18 (2.0) <5 (†) 0 (0.0) 67 (2.1)
Omphalocele 16 (0.9) <5 (†) 5 (0.5) 0 (0.0) 0 (0.0) 36 (1.2)
Pulmonary valve atresia 69 (3.7) 9 (5.8) 47 (5.1) 6 (4.5) <5 (†) 144 (4.6)
Pulmonary valve atresia and stenosis 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)
Rectal and large intestinal atresia / stenosis 88 (4.8) 7 (4.5) 47 (5.1) 7 (5.3) 0 (0.0) 155 (5.0)
Renal agenesis / hypoplasia 118 (6.4) 7 (4.5) 53 (5.8) 10 (7.5) 0 (0.0) 205 (6.6)
Single ventricle <5 (†) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) 6 (0.2)
Small intestinal atresia / stenosis 68 (3.7) 7 (4.5) 40 (4.4) 0 (0.0) 0 (0.0) 122 (3.9)
Spina bifida without anencephaly 26 (1.4) <5 (†) 14 (1.5) <5 (†) <5 (†) 50 (1.6)
Tetralogy of Fallot (TOF) 48 (2.6) <5 (†) 22 (2.4) <5 (†) <5 (†) 81 (2.6)
Total anomalous pulmonary venous connection (TAPVC) 5 (0.3) <5 (†) 9 (1.0) 0 (0.0) 0 (0.0) 21 (0.7)
Transposition of the great arteries (TGA) 27 (1.5) <5 (†) 11 (1.2) 0 (0.0) 0 (0.0) 44 (1.4)
Tricuspid valve atresia 6 (0.3) 0 (0.0) <5 (†) <5 (†) 0 (0.0) 13 (0.4)
Tricuspid valve atresia and stenosis 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)
Trisomy 13 8 (0.4) 0 (0.0) 6 (0.7) <5 (†) 0 (0.0) 35 (1.1)
Trisomy 18 14 (0.8) 0 (0.0) 7 (0.8) 0 (0.0) 0 (0.0) 67 (2.1)
Trisomy 21 (Down syndrome) 168 (9.1) 24 (15.5) 116 (12.7) 5 (3.8) 0 (0.0) 425 (13.6)
Turner syndrome 45 (5.0) <5 (†) 16 (3.6) <5 (†) 0 (0.0) 83 (5.4) 2
Ventricular septal defect 1015 (55.0) 85 (54.9) 536 (58.6) 60 (45.2) 22 (122.6) 1787 (57.1)
Total live births 184627 15488 91434 13276 1794 312733 3
Male Live Births 94609 7773 46745 6816 903 160035
Female Live Births 90018 7715 44689 6460 891 152698
Notes
1- Data for this condition include male and unknown infant sex cases only. Prevalence is calculated per 10,000 male live births.
2- Data for this condition include female and unknown infant sex cases only. Prevalence is calculated per 10,000 female live births.
3- Data for total live births include unknown infant sex.

General comments
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other race
Colorado
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Age
Total *
Less than 35 years 35 of more years
Gastroschisis 59 (2.5) <5 (†) 60 (1.9)
Trisomy 13 13 (0.6) 9 (1.2) 35 (1.1)
Trisomy 18 10 (0.4) 25 (3.2) 67 (2.1)
Trisomy 21 (Down syndrome) 164 (7.0) 173 (22.4) 425 (13.6)
Total live births 235606 77068 312733
Notes
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other maternal age
Colorado
Notes on Specific Birth Defects
Defect Site Comment
Universal comment Data for all conditions may differ from previous reports due to a shift to a passive surveillance system beginning with 2021 data