Florida
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Race/Ethnicity
Total * Notes
White,
Non-Hispanic
Black,
Non-Hispanic
Hispanic,
Non-Hispanic
Asian or
Pacific Islander,
Non-Hispanic
American Indian
or Alaskan Native,
Non-Hispanic
Anencephaly 37 (0.8) 20 (0.9) 28 (0.8) <5 (†) 0 (0.0) 91 (0.8)
Anophthalmia / microphthalmia 36 (0.8) 32 (1.4) 39 (1.1) <5 (†) 0 (0.0) 119 (1.1)
Anotia / microtia 56 (1.3) 23 (1.0) 76 (2.2) <5 (†) 0 (0.0) 166 (1.5)
Aortic valve stenosis 64 (1.4) 16 (0.7) 28 (0.8) <5 (†) <5 (†) 119 (1.1)
Atrial septal defect 4590 (103.7) 3210 (142.0) 4306 (125.9) 343 (105.4) 14 (128.4) 12884 (118.7)
Atrioventricular septal defect (endocardial cushion defect) 203 (4.6) 147 (6.5) 112 (3.3) 10 (3.1) <5 (†) 491 (4.5)
Biliary atresia 83 (1.9) 124 (5.5) 74 (2.2) 11 (3.4) 0 (0.0) 300 (2.8)
Bladder exstrophy 14 (0.3) 5 (0.2) <5 (†) 0 (0.0) 0 (0.0) 23 (0.2)
Choanal atresia 73 (1.6) 38 (1.7) 38 (1.1) 6 (1.8) 0 (0.0) 158 (1.5)
Cleft lip alone (without cleft palate) 158 (3.6) 33 (1.5) 62 (1.8) 12 (3.7) <5 (†) 275 (2.5)
Cleft lip with cleft palate 244 (5.5) 85 (3.8) 163 (4.8) 14 (4.3) <5 (†) 530 (4.9)
Cleft palate alone (without cleft lip) 273 (6.2) 78 (3.5) 145 (4.2) 18 (5.5) 0 (0.0) 533 (4.9)
Cloacal exstrophy 5 (0.1) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 8 (0.1)
Clubfoot 1082 (24.4) 479 (21.2) 747 (21.8) 65 (20.0) <5 (†) 2476 (22.8)
Coarctation of aorta 282 (6.4) 142 (6.3) 200 (5.8) 19 (5.8) 0 (0.0) 664 (6.1)
Common truncus (truncus arteriosus or TA) 14 (0.3) 8 (0.4) 12 (0.4) <5 (†) 0 (0.0) 36 (0.3)
Congenital cataract 39 (0.9) 40 (1.8) 43 (1.3) 0 (0.0) 0 (0.0) 125 (1.2)
Congenital posterior urethral valves 53 (2.3) 50 (4.4) 28 (1.6) 5 (3.0) 0 (0.0) 141 (2.5) 1
Craniosynostosis 243 (5.5) 66 (2.9) 149 (4.4) 13 (4.0) <5 (†) 480 (4.4)
Deletion 22q11.2 13 (0.3) 13 (0.6) 16 (0.5) <5 (†) 0 (0.0) 44 (0.4)
Dextro-Transposition of great arteries (d-TGA) 122 (2.8) 60 (2.7) 80 (2.3) 10 (3.1) 0 (0.0) 280 (2.6)
Diaphragmatic hernia 166 (3.8) 91 (4.0) 108 (3.2) 16 (4.9) 0 (0.0) 390 (3.6)
Double outlet right ventricle (DORV) 90 (2.0) 83 (3.7) 69 (2.0) <5 (†) 0 (0.0) 250 (2.3)
Ebstein anomaly 27 (0.6) 13 (0.6) 27 (0.8) <5 (†) 0 (0.0) 80 (0.7)
Encephalocele 46 (1.0) 22 (1.0) 22 (0.6) <5 (†) 0 (0.0) 93 (0.9)
Esophageal atresia / tracheoesophageal fistula 119 (2.7) 48 (2.1) 79 (2.3) 7 (2.2) <5 (†) 272 (2.5)
Gastroschisis 168 (3.8) 45 (2.0) 115 (3.4) <5 (†) 0 (0.0) 337 (3.1)
Holoprosencephaly 37 (0.8) 27 (1.2) 24 (0.7) <5 (†) 0 (0.0) 94 (0.9)
Hypoplastic left heart syndrome 130 (2.9) 91 (4.0) 89 (2.6) 5 (1.5) 0 (0.0) 326 (3.0)
Hypospadias 2078 (91.6) 770 (67.1) 957 (54.6) 105 (62.8) <5 (†) 4058 (73.1) 1
Interrupted aortic arch (IAA) 33 (0.7) 15 (0.7) 18 (0.5) 0 (0.0) 0 (0.0) 69 (0.6)
Limb deficiencies (reduction defects) 114 (2.6) 88 (3.9) 89 (2.6) <5 (†) 0 (0.0) 307 (2.8)
Omphalocele 81 (1.8) 76 (3.4) 50 (1.5) 0 (0.0) 0 (0.0) 215 (2.0)
Pulmonary valve atresia 22 (0.5) 9 (0.4) 21 (0.6) <5 (†) 0 (0.0) 58 (0.5)
Pulmonary valve atresia and stenosis 282 (6.4) 253 (11.2) 381 (11.1) 13 (4.0) 0 (0.0) 980 (9.0)
Rectal and large intestinal atresia / stenosis 155 (3.5) 88 (3.9) 136 (4.0) 13 (4.0) <5 (†) 406 (3.7)
Renal agenesis / hypoplasia 289 (6.5) 159 (7.0) 204 (6.0) 17 (5.2) 0 (0.0) 696 (6.4)
Single ventricle 59 (1.3) 33 (1.5) 35 (1.0) <5 (†) 0 (0.0) 135 (1.2)
Small intestinal atresia / stenosis 157 (3.5) 97 (4.3) 111 (3.2) <5 (†) 0 (0.0) 380 (3.5)
Spina bifida without anencephaly 134 (3.0) 41 (1.8) 86 (2.5) <5 (†) 0 (0.0) 272 (2.5)
Tetralogy of Fallot (TOF) 216 (4.9) 157 (6.9) 134 (3.9) 13 (4.0) <5 (†) 541 (5.0)
Total anomalous pulmonary venous connection (TAPVC) 31 (0.7) 20 (0.9) 30 (0.9) 0 (0.0) 0 (0.0) 87 (0.8)
Transposition of the great arteries (TGA) 131 (3.0) 60 (2.7) 82 (2.4) 10 (3.1) 0 (0.0) 292 (2.7)
Tricuspid valve atresia 40 (0.9) 18 (0.8) 34 (1.0) <5 (†) 0 (0.0) 94 (0.9)
Tricuspid valve atresia and stenosis 40 (0.9) 18 (0.8) 34 (1.0) <5 (†) 0 (0.0) 94 (0.9)
Trisomy 13 36 (0.8) 37 (1.6) 21 (0.6) 5 (1.5) 0 (0.0) 106 (1.0)
Trisomy 18 65 (1.5) 78 (3.5) 53 (1.5) <5 (†) <5 (†) 212 (2.0)
Trisomy 21 (Down syndrome) 528 (11.9) 359 (15.9) 429 (12.5) 24 (7.4) <5 (†) 1398 (12.9)
Turner syndrome 78 (3.6) 24 (2.2) 41 (2.5) 5 (3.2) 0 (0.0) 154 (2.9) 2
Ventricular septal defect 2802 (63.3) 1492 (66.0) 2242 (65.6) 178 (54.7) 11 (100.9) 6950 (64.0)
Total live births 442616 226014 341953 32538 1090 1085278 3
Male Live Births 226877 114764 175184 16710 541 555052
Female Live Births 215733 111247 166762 15826 549 530207
Notes
1- Data for this condition include male and unknown infant sex cases only. Prevalence is calculated per 10,000 male live births.
2- Data for this condition include female and unknown infant sex cases only. Prevalence is calculated per 10,000 female live births.
3- Data for total live births include unknown infant sex.

General comments
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other race
Florida
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Age
Total *
Less than 35 years 35 of more years
Gastroschisis 321 (3.7) 16 (0.7) 337 (3.1)
Trisomy 13 47 (0.5) 59 (2.7) 106 (1.0)
Trisomy 18 86 (1.0) 125 (5.6) 212 (2.0)
Trisomy 21 (Down syndrome) 607 (7.0) 791 (35.8) 1398 (12.9)
Total live births 863971 221247 1085278
Notes
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other maternal age
Florida
Notes on Specific Birth Defects
Defect Site Comment
Tetralogy of Fallot (TOF) Pulmonary atresia with a ventricular septal defect was included as Tetralogy of Fallot.
Ventricular septal defect Data for this condition include probable cases.
Atrioventricular septal defect (endocardial cushion defect) Data for this condition include canal type atrioventricular septal defect.
Pulmonary valve atresia Cases with Tetralogy of Fallot or ventricular septal defect were excluded.
Tricuspid valve atresia and stenosis Data for this condition include congenital tricuspid stenosis.
Tricuspid valve atresia Data for this condition include congenital tricuspid stenosis.
Gastroschisis Data for this condition may differ from previous reports due to ICD-9-CM coding system changes.
Omphalocele Data for this condition may differ from previous reports due to ICD-9-CM coding system changes.
Hypospadias Hypospadias prevalence per 10,000 male live births.
Turner syndrome Turner syndrome prevalence per 10,000 female live births. Excludes male phenotype.
Congenital posterior urethral valves Congenital posterior urethral valve prevalence per 10,000 male live births.
Interrupted aortic arch (IAA) For interrupted aortic arch (IAA), Florida has decided NEVER to use the Q25.2 and Q25.4 codes due to lack of specificity for IAA.
Universal comment Total live births includes unknown gender.
Universal comment Only live birth outcomes are considered. Linkage rates between birth certificates and hospital discharge data, which are used to identify codes indicative of birth defects went down during the 2018-2022 study period, which could result in an artifical decrease in defect rates.