Kentucky
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Race/Ethnicity
Total * Notes
White,
Non-Hispanic
Black,
Non-Hispanic
Hispanic,
Non-Hispanic
Asian or
Pacific Islander,
Non-Hispanic
American Indian
or Alaskan Native,
Non-Hispanic
Anencephaly 46 (2.2) 6 (2.4) 7 (4.0) <5 (†) 0 (0.0) 64 (2.4)
Anophthalmia / microphthalmia 13 (0.6) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 17 (0.6)
Anotia / microtia 25 (1.2) <5 (†) 7 (4.0) <5 (†) 0 (0.0) 38 (1.4)
Aortic valve stenosis 20 (1.0) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 23 (0.9)
Atrial septal defect 5714 (276.0) 1303 (522.3) 596 (342.3) 160 (566.8) 9 (340.9) 8106 (308.0)
Atrioventricular septal defect (endocardial cushion defect) 85 (4.1) 10 (4.0) 6 (3.4) <5 (†) 0 (0.0) 105 (4.0)
Biliary atresia 12 (0.6) 5 (2.0) <5 (†) <5 (†) 0 (0.0) 22 (0.8)
Bladder exstrophy <5 (†) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 5 (0.2)
Choanal atresia 26 (1.3) <5 (†) 0 (0.0) <5 (†) 0 (0.0) 30 (1.1)
Cleft lip alone (without cleft palate) 72 (3.5) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 79 (3.0)
Cleft lip with cleft palate 129 (6.2) 16 (6.4) 13 (7.5) <5 (†) <5 (†) 165 (6.3)
Cleft palate alone (without cleft lip) 154 (7.4) 10 (4.0) 5 (2.9) 5 (17.7) 0 (0.0) 179 (6.8)
Cloacal exstrophy 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) <5 (†)
Clubfoot 405 (19.6) 48 (19.2) 24 (13.8) 7 (24.8) 0 (0.0) 511 (19.4)
Coarctation of aorta 95 (4.6) 8 (3.2) 12 (6.9) <5 (†) 0 (0.0) 120 (4.6)
Common truncus (truncus arteriosus or TA) 9 (0.4) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 13 (0.5)
Congenital cataract 17 (0.8) 0 (0.0) <5 (†) <5 (†) 0 (0.0) 23 (0.9)
Congenital posterior urethral valves 17 (1.6) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 22 (1.6) 1
Deletion 22q11.2 20 (1.0) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 25 (0.9)
Dextro-Transposition of great arteries (d-TGA) 76 (3.7) 8 (3.2) 8 (4.6) <5 (†) 0 (0.0) 94 (3.6)
Diaphragmatic hernia 55 (2.7) 10 (4.0) 11 (6.3) <5 (†) 0 (0.0) 89 (3.4)
Double outlet right ventricle (DORV) 50 (2.4) 12 (4.8) 8 (4.6) <5 (†) 0 (0.0) 75 (2.8)
Ebstein anomaly 13 (0.6) 0 (0.0) <5 (†) <5 (†) 0 (0.0) 17 (0.6)
Encephalocele 19 (0.9) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 24 (0.9)
Esophageal atresia / tracheoesophageal fistula 45 (2.2) 5 (2.0) <5 (†) <5 (†) 0 (0.0) 57 (2.2)
Gastroschisis 102 (4.9) 12 (4.8) 5 (2.9) 0 (0.0) 0 (0.0) 123 (4.7)
Holoprosencephaly 19 (0.9) <5 (†) <5 (†) <5 (†) 0 (0.0) 26 (1.0)
Hypoplastic left heart syndrome 47 (2.3) 12 (4.8) 6 (3.4) 0 (0.0) 0 (0.0) 67 (2.5)
Hypospadias 917 (86.3) 98 (78.3) 38 (43.7) 13 (92.9) <5 (†) 1098 (81.7) 1
Interrupted aortic arch (IAA) 10 (0.5) <5 (†) <5 (†) 0 (0.0) 0 (0.0) 14 (0.5)
Limb deficiencies (reduction defects) 79 (3.8) 10 (4.0) 8 (4.6) <5 (†) 0 (0.0) 100 (3.8)
Omphalocele 51 (2.5) 8 (3.2) 5 (2.9) <5 (†) 0 (0.0) 66 (2.5)
Pulmonary valve atresia 14 (0.7) <5 (†) <5 (†) <5 (†) 0 (0.0) 22 (0.8)
Pulmonary valve atresia and stenosis 122 (5.9) 17 (6.8) 15 (8.6) <5 (†) 0 (0.0) 161 (6.1)
Rectal and large intestinal atresia / stenosis 86 (4.2) 9 (3.6) 11 (6.3) <5 (†) 0 (0.0) 113 (4.3)
Renal agenesis / hypoplasia 130 (6.3) 20 (8.0) 14 (8.0) 5 (17.7) <5 (†) 177 (6.7)
Single ventricle <5 (†) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) <5 (†)
Small intestinal atresia / stenosis 60 (2.9) 13 (5.2) 10 (5.7) <5 (†) 0 (0.0) 86 (3.3)
Spina bifida without anencephaly 66 (3.2) 12 (4.8) 6 (3.4) <5 (†) 0 (0.0) 87 (3.3)
Tetralogy of Fallot (TOF) 72 (3.5) 16 (6.4) 6 (3.4) <5 (†) <5 (†) 100 (3.8)
Total anomalous pulmonary venous connection (TAPVC) 24 (1.2) <5 (†) <5 (†) <5 (†) 0 (0.0) 28 (1.1)
Transposition of the great arteries (TGA) 78 (3.8) 8 (3.2) 8 (4.6) <5 (†) 0 (0.0) 96 (3.6)
Tricuspid valve atresia 15 (0.7) <5 (†) 0 (0.0) <5 (†) 0 (0.0) 17 (0.6)
Trisomy 13 25 (1.2) 9 (3.6) <5 (†) 0 (0.0) 0 (0.0) 40 (1.5)
Trisomy 18 48 (2.3) 11 (4.4) 5 (2.9) 0 (0.0) 0 (0.0) 65 (2.5)
Trisomy 21 (Down syndrome) 221 (10.7) 36 (14.4) 35 (20.1) 8 (28.3) 0 (0.0) 330 (12.5)
Turner syndrome 39 (3.9) <5 (†) <5 (†) <5 (†) 0 (0.0) 47 (3.6) 2
Ventricular septal defect 1236 (59.7) 189 (75.8) 148 (85.0) 37 (131.1) <5 (†) 1698 (64.5)
Total live births 207041 24948 17410 2823 264 263206 3
Male Live Births 106217 12517 8700 1400 131 134373
Female Live Births 100812 12430 8710 1423 133 128820
Notes
1- Data for this condition include male and unknown infant sex cases only. Prevalence is calculated per 10,000 male live births.
2- Data for this condition include female and unknown infant sex cases only. Prevalence is calculated per 10,000 female live births.
3- Data for total live births include unknown infant sex.

General comments
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other race
Kentucky
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Age
Total *
Less than 35 years 35 of more years
Gastroschisis 112 (5.1) 8 (2.4) 123 (4.7)
Trisomy 13 25 (1.1) 14 (4.2) 40 (1.5)
Trisomy 18 36 (1.6) 29 (8.7) 65 (2.5)
Trisomy 21 (Down syndrome) 172 (7.8) 135 (40.4) 330 (12.5)
Total live births 221344 33449 263206
Notes
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other maternal age
Kentucky
Notes on Specific Birth Defects
Defect Site Comment
Universal comment The differences shown in the sheet for the "Check total Race LB" and "Check total Sex LB" is due to the added data under the "unknown gender" category. The Unknown gender category was added due to it being on the SAS data file but the excel sheet does not include it in the automatic calculation it does in the "Totals" tab because the "unknown gender" category is newly added.
Universal comment The differences shown in the sheet for the "Check total All LB" is due to the added data under the "unknown gender" category. The Unknown gender category was added due to it being on the SAS data file but the excel sheet does not include it in the automatic calculation it does in the "Totals" tab because the "unknown gender" category is newly added.