| North Carolina Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births) |
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| Defect |
Maternal Race/Ethnicity
|
Total * | Notes | ||||
|---|---|---|---|---|---|---|---|
| White, Non-Hispanic |
Black, Non-Hispanic |
Hispanic, Non-Hispanic |
Asian or Pacific Islander, Non-Hispanic |
American Indian or Alaskan Native, Non-Hispanic |
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| Anencephaly | 41 (1.3) | 15 (1.1) | 17 (1.7) | <5 (†) | <5 (†) | 94 (1.6) | |
| Anophthalmia / microphthalmia | 32 (1.0) | 15 (1.1) | 10 (1.0) | <5 (†) | <5 (†) | 64 (1.1) | |
| Anotia / microtia | 44 (1.4) | 13 (0.9) | 59 (5.9) | 9 (3.5) | <5 (†) | 127 (2.1) | |
| Aortic valve stenosis | 86 (2.7) | 24 (1.7) | 18 (1.8) | <5 (†) | <5 (†) | 135 (2.3) | |
| Atrial septal defect | 1589 (50.1) | 873 (62.0) | 539 (53.8) | 93 (36.2) | 58 (75.6) | 3188 (53.4) | |
| Atrioventricular septal defect (endocardial cushion defect) | 241 (7.6) | 145 (10.3) | 72 (7.2) | 16 (6.2) | 5 (6.5) | 488 (8.2) | |
| Biliary atresia | 17 (0.5) | 17 (1.2) | 8 (0.8) | <5 (†) | 0 (0.0) | 45 (0.8) | |
| Bladder exstrophy | 11 (0.3) | <5 (†) | 0 (0.0) | <5 (†) | 0 (0.0) | 16 (0.3) | |
| Choanal atresia | 32 (1.0) | 15 (1.1) | 12 (1.2) | <5 (†) | <5 (†) | 65 (1.1) | |
| Cleft lip alone (without cleft palate) | 111 (3.5) | 33 (2.3) | 27 (2.7) | 9 (3.5) | 0 (0.0) | 185 (3.1) | |
| Cleft lip with cleft palate | 167 (5.3) | 42 (3.0) | 53 (5.3) | 12 (4.7) | 7 (9.1) | 286 (4.8) | |
| Cleft palate alone (without cleft lip) | 211 (6.7) | 61 (4.3) | 51 (5.1) | 19 (7.4) | 11 (14.3) | 356 (6.0) | |
| Cloacal exstrophy | <5 (†) | 0 (0.0) | <5 (†) | 0 (0.0) | 0 (0.0) | 7 (0.1) | |
| Clubfoot | 377 (11.9) | 124 (8.8) | 97 (9.7) | 21 (8.2) | 9 (11.7) | 635 (10.6) | |
| Coarctation of aorta | 166 (5.2) | 68 (4.8) | 46 (4.6) | <5 (†) | <5 (†) | 288 (4.8) | |
| Common truncus (truncus arteriosus or TA) | 16 (0.5) | 13 (0.9) | 11 (1.1) | 0 (0.0) | <5 (†) | 41 (0.7) | |
| Congenital cataract | 17 (0.5) | 23 (1.6) | 7 (0.7) | <5 (†) | 0 (0.0) | 49 (0.8) | |
| Congenital posterior urethral valves | 28 (1.7) | 25 (3.5) | <5 (†) | <5 (†) | <5 (†) | 60 (2.0) | 1 |
| Craniosynostosis | 223 (7.0) | 38 (2.7) | 65 (6.5) | 14 (5.5) | 5 (6.5) | 349 (5.9) | |
| Deletion 22q11.2 | 38 (1.2) | 21 (1.5) | 17 (1.7) | 0 (0.0) | <5 (†) | 77 (1.3) | |
| Dextro-Transposition of great arteries (d-TGA) | 123 (3.9) | 38 (2.7) | 29 (2.9) | <5 (†) | <5 (†) | 200 (3.4) | |
| Diaphragmatic hernia | 107 (3.4) | 37 (2.6) | 33 (3.3) | <5 (†) | 5 (6.5) | 189 (3.2) | |
| Double outlet right ventricle (DORV) | 53 (1.7) | 31 (2.2) | 25 (2.5) | <5 (†) | 0 (0.0) | 116 (1.9) | |
| Ebstein anomaly | 19 (0.6) | 10 (0.7) | 10 (1.0) | <5 (†) | 0 (0.0) | 43 (0.7) | |
| Encephalocele | 26 (0.8) | 14 (1.0) | 7 (0.7) | <5 (†) | <5 (†) | 52 (0.9) | |
| Esophageal atresia / tracheoesophageal fistula | 72 (2.3) | 28 (2.0) | 19 (1.9) | <5 (†) | <5 (†) | 127 (2.1) | |
| Gastroschisis | 110 (3.5) | 36 (2.6) | 46 (4.6) | 9 (3.5) | 7 (9.1) | 214 (3.6) | |
| Holoprosencephaly | 24 (0.8) | 18 (1.3) | 9 (0.9) | 0 (0.0) | <5 (†) | 61 (1.0) | |
| Hypoplastic left heart syndrome | 89 (2.8) | 51 (3.6) | 27 (2.7) | <5 (†) | 0 (0.0) | 170 (2.8) | |
| Hypospadias | 1153 (70.8) | 413 (57.8) | 163 (32.0) | 70 (53.9) | 18 (46.3) | 1828 (60.0) | 1 |
| Interrupted aortic arch (IAA) | 20 (0.6) | 20 (1.4) | 10 (1.0) | <5 (†) | 0 (0.0) | 52 (0.9) | |
| Limb deficiencies (reduction defects) | 100 (3.2) | 71 (5.0) | 47 (4.7) | 5 (1.9) | 9 (11.7) | 238 (4.0) | |
| Omphalocele | 65 (2.1) | 42 (3.0) | 21 (2.1) | 6 (2.3) | <5 (†) | 141 (2.4) | |
| Pulmonary valve atresia | 31 (1.0) | 25 (1.8) | 16 (1.6) | <5 (†) | <5 (†) | 78 (1.3) | |
| Pulmonary valve atresia and stenosis | 297 (9.4) | 157 (11.2) | 83 (8.3) | 17 (6.6) | 12 (15.7) | 573 (9.6) | |
| Rectal and large intestinal atresia / stenosis | 128 (4.0) | 46 (3.3) | 43 (4.3) | 13 (5.1) | <5 (†) | 236 (4.0) | |
| Renal agenesis / hypoplasia | 223 (7.0) | 101 (7.2) | 58 (5.8) | 9 (3.5) | <5 (†) | 406 (6.8) | |
| Single ventricle | 18 (0.6) | 9 (0.6) | 11 (1.1) | 0 (0.0) | 0 (0.0) | 39 (0.7) | |
| Small intestinal atresia / stenosis | 100 (3.2) | 62 (4.4) | 35 (3.5) | 6 (2.3) | <5 (†) | 207 (3.5) | |
| Spina bifida without anencephaly | 108 (3.4) | 23 (1.6) | 36 (3.6) | 5 (1.9) | <5 (†) | 182 (3.1) | |
| Tetralogy of Fallot (TOF) | 162 (5.1) | 86 (6.1) | 49 (4.9) | 17 (6.6) | 7 (9.1) | 322 (5.4) | |
| Total anomalous pulmonary venous connection (TAPVC) | 47 (1.5) | 24 (1.7) | 20 (2.0) | <5 (†) | <5 (†) | 95 (1.6) | |
| Transposition of the great arteries (TGA) | 131 (4.1) | 42 (3.0) | 31 (3.1) | <5 (†) | <5 (†) | 214 (3.6) | |
| Tricuspid valve atresia | 43 (1.4) | 32 (2.3) | 15 (1.5) | <5 (†) | <5 (†) | 92 (1.5) | |
| Tricuspid valve atresia and stenosis | 55 (1.7) | 36 (2.6) | 22 (2.2) | <5 (†) | <5 (†) | 117 (2.0) | |
| Trisomy 13 | 34 (1.1) | 24 (1.7) | 13 (1.3) | <5 (†) | <5 (†) | 80 (1.3) | |
| Trisomy 18 | 71 (2.2) | 48 (3.4) | 34 (3.4) | <5 (†) | <5 (†) | 178 (3.0) | |
| Trisomy 21 (Down syndrome) | 354 (11.2) | 150 (10.7) | 215 (21.5) | 30 (11.7) | 14 (18.3) | 794 (13.3) | |
| Turner syndrome | 49 (3.2) | 17 (2.5) | 16 (3.3) | <5 (†) | 0 (0.0) | 94 (3.2) | 2 |
| Ventricular septal defect | 1549 (48.9) | 713 (50.7) | 637 (63.6) | 99 (38.6) | 39 (50.9) | 3065 (51.4) | |
| Total live births | 316934 | 140741 | 100095 | 25679 | 7667 | 596503 | 3 |
| Male Live Births | 162872 | 71464 | 50902 | 12996 | 3887 | 304856 | |
| Female Live Births | 154061 | 69271 | 49192 | 12683 | 3780 | 291639 | |
| Notes 1- Data for this condition include male and unknown infant sex cases only. Prevalence is calculated per 10,000 male live births. 2- Data for this condition include female and unknown infant sex cases only. Prevalence is calculated per 10,000 female live births. 3- Data for total live births include unknown infant sex. General comments †- Counts <5 and associated prevalences are suppressed *- Data for totals include unknown/other race |
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| North Carolina Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births) |
|||
| Defect |
Maternal Age
|
Total * | |
|---|---|---|---|
| Less than 35 years | 35 of more years | ||
| Gastroschisis | 204 (4.1) | 9 (0.9) | 214 (3.6) |
| Trisomy 13 | 46 (0.9) | 33 (3.2) | 80 (1.3) |
| Trisomy 18 | 95 (1.9) | 83 (8.1) | 178 (3.0) |
| Trisomy 21 (Down syndrome) | 360 (7.3) | 433 (42.5) | 794 (13.3) |
| Total live births | 494499 | 101982 | 596503 |
| Notes †- Counts <5 and associated prevalences are suppressed *- Data for totals include unknown/other maternal age |
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