Puerto Rico
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Race/Ethnicity
Total * Notes
White,
Non-Hispanic
Black,
Non-Hispanic
Hispanic,
Non-Hispanic
Asian or
Pacific Islander,
Non-Hispanic
American Indian
or Alaskan Native,
Non-Hispanic
Anencephaly 0 (0.0) 0 (0.0) 29 (3.0) 0 (0.0) 0 (0.0) 37 (3.7)
Anophthalmia / microphthalmia 0 (0.0) 0 (0.0) 14 (1.4) 0 (0.0) 0 (0.0) 14 (1.4)
Anotia / microtia <5 (†) 0 (0.0) 14 (1.4) 0 (0.0) 0 (0.0) 15 (1.5)
Aortic valve stenosis 0 (0.0) 0 (0.0) 14 (1.4) 0 (0.0) 0 (0.0) 15 (1.5)
Atrial septal defect 5 (26.5) <5 (†) 335 (34.5) 0 (0.0) 0 (0.0) 342 (34.4)
Atrioventricular septal defect (endocardial cushion defect) <5 (†) 0 (0.0) 43 (4.4) 0 (0.0) 0 (0.0) 45 (4.5)
Bladder exstrophy <5 (†) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) <5 (†)
Cleft lip alone (without cleft palate) 0 (0.0) 0 (0.0) 42 (4.3) 0 (0.0) 0 (0.0) 44 (4.4)
Cleft lip with cleft palate 0 (0.0) 0 (0.0) 59 (6.1) <5 (†) 0 (0.0) 60 (6.0)
Cleft palate alone (without cleft lip) 0 (0.0) 0 (0.0) 62 (6.4) 0 (0.0) 0 (0.0) 62 (6.2)
Clubfoot <5 (†) 0 (0.0) 193 (19.9) <5 (†) 0 (0.0) 202 (20.3)
Coarctation of aorta 0 (0.0) 0 (0.0) 42 (4.3) 0 (0.0) 0 (0.0) 42 (4.2)
Common truncus (truncus arteriosus or TA) 0 (0.0) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) <5 (†)
Congenital cataract 0 (0.0) 0 (0.0) 27 (2.8) 0 (0.0) 0 (0.0) 27 (2.7)
Craniosynostosis <5 (†) 0 (0.0) 23 (2.4) 0 (0.0) 0 (0.0) 24 (2.4)
Deletion 22q11.2 <5 (†) 0 (0.0) 5 (0.5) 0 (0.0) 0 (0.0) 6 (0.6)
Dextro-Transposition of great arteries (d-TGA) 0 (0.0) 0 (0.0) 12 (1.2) 0 (0.0) 0 (0.0) 12 (1.2)
Diaphragmatic hernia 0 (0.0) 0 (0.0) 23 (2.4) 0 (0.0) 0 (0.0) 24 (2.4)
Double outlet right ventricle (DORV) 0 (0.0) 0 (0.0) 22 (2.3) 0 (0.0) 0 (0.0) 22 (2.2)
Ebstein anomaly 0 (0.0) 0 (0.0) 8 (0.8) 0 (0.0) 0 (0.0) 8 (0.8)
Encephalocele 0 (0.0) 0 (0.0) 10 (1.0) 0 (0.0) 0 (0.0) 14 (1.4)
Esophageal atresia / tracheoesophageal fistula 0 (0.0) 0 (0.0) 11 (2.9) 0 (0.0) 0 (0.0) 11 (2.9)
Gastroschisis <5 (†) 0 (0.0) 56 (5.8) 0 (0.0) 0 (0.0) 58 (5.8)
Holoprosencephaly <5 (†) 0 (0.0) 25 (2.6) 0 (0.0) 0 (0.0) 30 (3.0)
Hypoplastic left heart syndrome 0 (0.0) 0 (0.0) 25 (2.6) 0 (0.0) 0 (0.0) 27 (2.7)
Hypospadias 10 (103.0) <5 (†) 363 (72.9) 0 (0.0) 0 (0.0) 375 (73.5) 1
Interrupted aortic arch (IAA) 0 (0.0) 0 (0.0) 5 (0.5) 0 (0.0) 0 (0.0) 5 (0.5)
Limb deficiencies (reduction defects) <5 (†) 0 (0.0) 64 (6.6) 0 (0.0) 0 (0.0) 67 (6.7)
Omphalocele <5 (†) 0 (0.0) 35 (3.6) 0 (0.0) 0 (0.0) 38 (3.8)
Pulmonary valve atresia 0 (0.0) 0 (0.0) 8 (0.8) 0 (0.0) 0 (0.0) 8 (0.8)
Pulmonary valve atresia and stenosis <5 (†) 0 (0.0) 125 (12.9) 0 (0.0) 0 (0.0) 128 (12.9)
Single ventricle 0 (0.0) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) <5 (†)
Small intestinal atresia / stenosis 0 (0.0) 0 (0.0) 13 (3.5) 0 (0.0) 0 (0.0) 13 (3.4)
Spina bifida without anencephaly <5 (†) 0 (0.0) 32 (3.3) 0 (0.0) 0 (0.0) 35 (3.5)
Tetralogy of Fallot (TOF) 0 (0.0) 0 (0.0) 33 (3.4) 0 (0.0) 0 (0.0) 33 (3.3)
Total anomalous pulmonary venous connection (TAPVC) 0 (0.0) 0 (0.0) 10 (1.0) 0 (0.0) 0 (0.0) 10 (1.0)
Transposition of the great arteries (TGA) 0 (0.0) 0 (0.0) 24 (2.5) 0 (0.0) 0 (0.0) 24 (2.4)
Tricuspid valve atresia 0 (0.0) 0 (0.0) 11 (1.1) 0 (0.0) 0 (0.0) 11 (1.1)
Tricuspid valve atresia and stenosis 0 (0.0) 0 (0.0) 9 (0.9) 0 (0.0) 0 (0.0) 9 (0.9)
Trisomy 13 0 (0.0) 0 (0.0) <5 (†) 0 (0.0) 0 (0.0) <5 (†)
Trisomy 18 0 (0.0) 0 (0.0) 13 (1.3) 0 (0.0) 0 (0.0) 18 (1.8)
Trisomy 21 (Down syndrome) <5 (†) <5 (†) 120 (12.4) 0 (0.0) 0 (0.0) 127 (12.8)
Turner syndrome 0 (0.0) 0 (0.0) 7 (1.5) 0 (0.0) 0 (0.0) 8 (1.7) 2
Ventricular septal defect <5 (†) 0 (0.0) 460 (47.4) 0 (0.0) 0 (0.0) 463 (46.5)
Total live births 1886 279 97034 164 10 99510 3
Male Live Births 971 148 49762 77 3 51042
Female Live Births 914 131 47269 87 7 48464
Notes
1- Data for this condition include male and unknown infant sex cases only. Prevalence is calculated per 10,000 male live births.
2- Data for this condition include female and unknown infant sex cases only. Prevalence is calculated per 10,000 female live births.
3- Data for total live births include unknown infant sex.

General comments
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other race
Puerto Rico
Birth Defects Counts and Prevalence 2018-2022 (Prevalence per 10,000 Live Births)
Defect
Maternal Age
Total *
Less than 35 years 35 of more years
Gastroschisis 58 (6.7) 0 (0.0) 58 (5.8)
Trisomy 13 <5 (†) 0 (0.0) <5 (†)
Trisomy 18 12 (1.4) 6 (5.1) 18 (1.8)
Trisomy 21 (Down syndrome) 53 (6.1) 74 (63.3) 127 (12.8)
Total live births 86879 11689 99510
Notes
†- Counts <5 and associated prevalences are suppressed
*- Data for totals include unknown/other maternal age